Hi,
there is some direct support for tablets in RealWorld applications through IRealTimeStylus and WinTab (including pressure support only in the Brush tool (not Pencil tool)). These communicate with the application very differently than a normal mouse. It was only tested with few tablets as I cannot test with every device.
I do not know if you have tried other graphic software with direct table support (you could tell if it does if it has different reaction to a different pressure - for example more intense or wider line when pushing the pen more). It would be useful info if you have used some of that software without problems.
Anyway, I got some answers googling for "Huion Kamvas Pro 16 pen wrong place" including a video https://www.youtube.com/watch?v=AiELFtI-c_4 that has some advice - installing driver, changing working area, calibrating.

